Global Manufacturing Outreach

ATVIO is a part of Orgenesis Inc., global CMO network, which include MaSTherCell Europe, MaSTherCell Asia and MaSTherCell USA.

Using ATVIO's CMO services will allow you to reduce costs of infrastructures and time-to-market while focusing on the science and your clinical trials. ATVIO’s team of experts closely understands the needs and challenges our clients (cell or gene therapy companies) are facing and is dedicated to their success. ATVIO’s production facilities and staff are qualified according to cGMP guidelines and are highly experienced in aseptic manipulations of cells, allowing us to produce high quality products.

The manufacturing activities are performed in ISO5-ISO8 (grade A-C) facilities, and the processes are validated and fully documented following the EU and FDA guidelines.

ATVIO utilized its expertise in bioreactors to ensure cost effective and efficient virus manufacturing.

ATVIO focused on developing and manufacturing of viruses for the cell & gene therapy industry. Our main expertise is with the following viral vectors:

  • Retroviruses- Mainly used for gene delivery in somatic and germline gene therapies. The viral DNA is integrated into the host DNA. After the incorporation of the DNA, when the cell divides, all the descendants will contain the new gene. Retroviruses can infect only dividing cells.
  • Lentiviruses- Part of the Retrovirus family characterized by long incubation period. Lentiviruses vectors have high-efficiency infection of both dividing and non-dividing cells, low immunogenicity and long-term expression stability. These vectors can carry medium size transgenes (8kb)
  • Adenoviruses- These vectors have low host specificity and can deliver up to 38 kb DNA particles. The Adenoviruses vectors can infect both dividing and non-dividing cells. The viral genome does not integrate into the host genome which limiting the stability of the vector.